Trimethoprim-Sulfamethoxazole Revisited | Infectious ...
Sulfamethoxazole inhibits conversion of p-aminobenzoic acid to dihydropteroate. This synergy results in maximal antibacterial activity, which is often bactericidal. Trimethoprim /sulfamethoxazole (TMP/SMX) is available as a fixed combination consisting of a 1:5 ratio (80 mg TMP plus 400 mg SMX or a double-strength tablet of 160 mg TMP plus 800 mg SMX).
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