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types of efficacy of tilmicosin phosphatepulmotil premix

  • Efficacy of tilmicosin phosphate (Pulmotil premix) in

    A double-blind randomized clinical trial was carried out to investigate the efficacy of tilmicosin (Pulmotil premix) for the treatment of a clinical outbreak of Actinobacillus pleuropneumoniae infection in growing-finishing pigs. The effects of tilmicosin administration in the feed at 400 mg/kg and an injection therapy of clinically diseased pigs ...

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  • Efficacy of Tilmicosin Phosphate (Pulmotil® Premix) in ...

    2008-7-7 · A double‐blind randomized clinical trial was carried out to investigate the efficacy of tilmicosin (Pulmotil ® premix) for the treatment of a clinical outbreak of Actinobacillus pleuropneumoniae infection in growing–finishing pigs. The effects of tilmicosin administration in the feed at 400 mg/kg and an injection therapy of clinically diseased pigs with long‐acting oxytetracycline ...

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  • A comparative study of the preventive use of

    This study was conducted to compare the effects of a preventive in-feed medication programme using tilmicosin (Pulmotil 200 premix, Elanco Animal Health) at 200 p.p.m. with those of Mycoplasma hyopneumoniae (Mh) vaccination programme (Stellamune Mycoplasma, Pfizer Animal Health). A …

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  • Efficacy of enteric-coated tilmicosin granules in pigs ...

    Conclusion: The results showed that enteric-coated tilmicosin granules had obvious therapeutic effect on artificial infection, which could reduce the damage caused by the disease and reduce the mortality. Keywords: Actinobacillus pleuropneumoniae; Tilmicosin; artificial infection; enteric-coated granule; pig; pleuropneumonia.

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  • Tilmicosin enteric granules and premix to pigs ...

    The relative bioavailability of tilmicosin enteric granules to premix was 114.97 ± 7.19%, according to the AUC 0-t values. These results demonstrated that tilmicosin enteric granules produced faster tilmicosin absorption, slower elimination, larger tissue distribution, and higher bioavailability compared to the tilmicosin premix.

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  • Tilmicosin - an overview | ScienceDirect Topics

    Adverse reactions and side effects. Tilmicosin may be cardiotoxic in some animals. Injections to pigs have been fatal because of cardiotoxicity. The cardiac effects are increased heart rate and decreased contractility. However, administration of tilmicosin premix in feed of pigs has been safe. In dogs, tilmicosin injections have caused cardiac ...

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  • Tilmovet Premix (Canada) for Animal Use - Drugs.com

    2021-6-28 · Bentonite in feeds may affect the efficacy of tilmicosin. CAUTIONS: 1) The safety of tilmicosin has not been established in boars used for breeding. 2) The effects of TILMOVET Premix on bovine reproductive performance, pregnancy and lactation have not been determined. 3) The safety of TILMOVET Premix in pre-ruminant calves has not been established.

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  • Solid Lipid Nanoparticles for Duodenum Targeted

    Compared to commercial premix, although the TIL-SLNs did not improve the oral absorption of tilmicosin, the time to reach peak concentration (T max) was obviously shortened. After the enteric coating of the granules containing SLNs and P-gp inhibitor of polysorbate-80, the oral absorption of tilmicosin was improved 2.72 fold, and the T max was ...

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  • The dose regimen formulation of tilmicosin against ...

    2020-10-1 · The ex vivo antibacterial effects of tilmicosin premix after oral administration were quantified into three levels including: (1) bacteriostatic action (no change in bacterial count, E = 0), (2) bactericidal action (99.9% reduction in bacterial count, E = −3), and (3) bacterial elimination (99.99% reduction, E = −4). The dose was calculated by the using the following formula.

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  • Pharmaceutics | Free Full-Text | Solid Lipid

    After the enteric coating of the granules containing SLNs and P-gp inhibitor of polysorbate-80, the oral absorption of tilmicosin was improved 2.72 fold, and the Tmax was shortened by 2 h. The combination of duodenum-targeted release and P-gp inhibitors was an effective method …

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  • Improving the outcome of antimicrobial treatment for ...

    2017-4-27 · products containing EU tilmicosin 20%. Fig. 1. Three types of antibiotics with an ideal Pk profile with regards to efficacy. C n c e n t r a t i on C o n c e n t r a t i on MIC Time-dependent T>MIC Cmax Cmax Tmax Tmax Concentration-dependent Time Time n Tilmovet n Other tilmicosin premix n Other premix n Tilmovet Total drug exposure over time M ...

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  • Therapeutic efficacy of tilmicosin in ovine mammary ...

    2003-1-1 · The therapeutic activity of tilmicosin was studied in some bacterial infections responsible for mastitis and mammary pustular dermatitis in sheep. The research was carried out on 105 half-breed sheep, between 3- and 5-year-old, kept in loose housing. The animals were divided into two groups ( A and B) on the basis of clinical signs observed.

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  • Tilmovet Premix (Canada) for Animal Use - Drugs.com

    2021-6-28 · Bentonite in feeds may affect the efficacy of tilmicosin. CAUTIONS: 1) The safety of tilmicosin has not been established in boars used for breeding. 2) The effects of TILMOVET Premix on bovine reproductive performance, pregnancy and lactation have not been determined. 3) The safety of TILMOVET Premix in pre-ruminant calves has not been established.

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  • Veterinary Antibiotic-Tilmicosin - BALLYA

    2021-1-21 · According to the requirements, the mixing dosage is 200~400g/t, and the current market tilmicosin premix content is mostly 20%, that is, the concentration of 20% tilmicosin mixing material is 1~2kg/t, using multiple coating technology Tilmicosin has better efficacy in the same dosage.

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  • Postantibiotic and physiological effects of tilmicosin ...

    The presence of tilmicosin, tylosin and apramycin in the medium decreased the rate of growth of the bacterial strains tested using drug concentrations as low as 1/4 MIC. The postantibiotic effect (PAE) which is the suppression of optimal bacterial growth that persists after a short exposure (2 h) of microorganisms to an antibiotic was studied ...

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  • Effect of Bromhexine on the Pharmacokinetic of

    Tilmicosin standard concentrations of 0.03, 0.06, 0.15, 0.3, 0.6, 1.5 and 3 μg/ml and their corresponding peak responses are illustrated in Table (1) and Fig. (1), and Typical Chromatogram of tilmicosin are illustrated in Fig. (2). the calibration curve was calculated by linear regression equation method as y= 1538.5x + 21.755 where ‘y ...

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  • The dose regimen formulation of tilmicosin against ...

    In this study, the rational dose regimens of tilmicosin against Lawsonia intracellularis (L. intracellularis) were studied using pharmacokinetic-pharmacodynamic (PK-PD) model approach to provide a maximal efficacy.The healthy and infected pigs were orally administrated the tilmicosin premix at a single dose of 10 mg/kg, and then the plasma and ileum content were collected at different time points.

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  • Pharmacokinetics of tilmicosin in serum and milk of

    1997-1-1 · Efficacy of Pulmotil (Tilmicosin in premix form) against naturally-occurring pneumonia in growingfattening pigs. Proceedings of the European Association for Veterinary Pharmacology and Toxicology, 6th International Congress, Edinburgh, 7–11 August 1994 (1994), pp. 202-203.

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  • [PDF] Intracellular accumulation, subcellular

    Tilmicosin is a semi-synthetic macrolide antibiotic, currently approved for veterinary use in cattle and swine respiratory disease, and is in development for use in poultry mycoplasma air sacculitis. In order to provide an understanding of clinical efficacy, the in vitro interaction of tilmicosin with three types of chicken phagocytes (MQ-NCSU macrophages, monocyte-macrophages, and heterophils ...

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  • [PDF] The effect of tilmicosin in minimizing atrophic ...

    Methods: Recipient pigs, exposed to donor pigs that demonstrated clinical signs of PAR, either did not (NME group) or did (ME group) receive tilmicosin in feed for 3 weeks; a third Control group was neither exposed nor medicated. Pig weights and nasal swabs for bacterial culture were collected on study days 0, 21, and 42. Feed intake was also monitored.

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  • Pharmacokinetics and Efficacy of Tilmicosin in the ...

    2014-6-19 · Tilmicosin was administered intravenously and subcutaneously at a dose rate of 10 mg/kg bwt to determine its concentration in blood and bronchial secretion as well as its kinetic behavior in healthy and Pasteurella haemolytica type A1-infected calves. Sever acute bronchopneumonia was induced in 10 calves by inoculating them intra-tracheally with P. haemolytica type A1.

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  • Tilmicosin - an overview | ScienceDirect Topics

    Adverse reactions and side effects. Tilmicosin may be cardiotoxic in some animals. Injections to pigs have been fatal because of cardiotoxicity. The cardiac effects are increased heart rate and decreased contractility. However, administration of tilmicosin premix in feed of pigs has been safe. In dogs, tilmicosin injections have caused cardiac ...

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  • Determination of antibacterial agent tilmicosin in pig ...

    A rapid and sensitive high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated to quantify tilmicosin in pig plasma. Plasma samples were prepared by liquid-liquid extraction. Chromatographic separation was achieved on a C18 column (2.1 × 30 mm, 3.5 μm) using acetonitrile-water (90:10, v/v; water included 0.1% formic acid) as the mobile phase.

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  • Pharmacokinetics of Tilmicosin (Provitil Powder and ...

    A bioavailability and pharmacokinetics study of powder and liquid tilmicosin formulations was carried out in 18 healthy chickens according to a single-dose, two-period, two-sequence, crossover randomized design. The two formulations were Provitil and Pulmotil AC. Both drugs were administered to each chicken after an overnight fast on two treatment days separated by a 2-week washout period.

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  • Postantibiotic and physiological effects of tilmicosin ...

    The presence of tilmicosin, tylosin and apramycin in the medium decreased the rate of growth of the bacterial strains tested using drug concentrations as low as 1/4 MIC. The postantibiotic effect (PAE) which is the suppression of optimal bacterial growth that persists after a short exposure (2 h) of microorganisms to an antibiotic was studied ...

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  • Residue Depletion of Tilmicosin in Chicken Tissues ...

    2019-5-25 · A high-performance liquid chromatography (HPLC) method with detection at 290 nm was modified and validated for the determination of tilmicosin residues in broiler chicken tissues. The limits of detection (LOD) of the method were 0.01 μg/g for muscle and 0.025 μg/g for liver and kidney. Average recoveries ranged from 80.4 to 88.3%. Relative standard deviation values ranged from 5.2 to 12.1% ...

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  • Evaluation of the clinical efficacy of a water soluble ...

    2020-12-4 · The efficacy of a water soluble formulation of tylvalosin (Aivlosin® 625 mg/g granules) was evaluated in the treatment and metaphylaxis of Enzootic Pneumonia (EP) in pigs. In all four trials, pigs in the tylvalosin group were administered 10 mg tylvalosin/kg bodyweight in drinking water daily for 5 consecutive days (TVN). In a single-challenge study, pigs were inoculated with lung homogenate ...

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  • Optimization of Tilmicosin-Loaded Nanostructured

    Tilmicosin (TMS) is widely used to treat bacterial infections in veterinary medicine, but the clinical effect is limited by its poor solubility, bitterness, gastric instability, and intestinal efflux transport. Nanostructured lipid carriers (NLCs) are nowadays considered to be a promising vector of therapeutic drugs for oral administration. In this study, an orthogonal experimental design was ...

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  • poultry premix tilmicosin phosphate - Alibaba.com

    Show some love to your pets and livestock with unmatched poultry premix tilmicosin phosphate deals on Alibaba.com. The poultry premix tilmicosin phosphate will sustain them in …

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  • Find Unimaginable Offers on Premium tilmicosin

    The tilmicosin soluble powder come in different sizes, packaging styles, and designs to address the various concerns of individuals and groups. If you are a farmer with many animals, you will find tilmicosin soluble powder in large packages to provide you with optimal transportation convenience. If you are a pet lover and you have a single ...

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  • [PDF] Pharmacokinetics and Efficacy of Tilmicosin in

    Tilmicosin was administered intravenously and subcutaneously at a dose rate of 10 mg/kg bwt to determine its concentration in blood and bronchial secretion as well as its kinetic behavior in healthy and Pasteurella haemolytica type A1-infected calves. Sever acute bronchopneumonia was induced in 10 calves by inoculating them intra-tracheally with P. haemolytica type A1.

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  • Tilmicosin (TIL) - Medicating Ingredient Brochure ...

    Tilmicosin drug premixes should be blended into an intermediate mix (premix or supplement) and then mixed into the complete diet [total mixed ration (TMR)] to supply 12.5 mg tilmicosin 64 per kg of body weight (BW). The following is the calculation to determine the concentration of tilmicosin in the complete feed and the intermediate mix.

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  • ANNEX I LIST OF THE NAMES, PHARMACEUTICAL FORM,

    The CVMP accepts that a claim for efficacy at a dose of 8 to 16 mg/kg bw/day of tilmicosin (equivalent to 200 to 400 ppm in the feed) for a period of 15 to 21 days for prevention and treatment of respiratory infections in pigs has been demonstrated.

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  • Improving the outcome of antimicrobial treatment for ...

    2017-4-27 · products containing EU tilmicosin 20%. Fig. 1. Three types of antibiotics with an ideal Pk profile with regards to efficacy. C n c e n t r a t i on C o n c e n t r a t i on MIC Time-dependent T>MIC Cmax Cmax Tmax Tmax Concentration-dependent Time Time n Tilmovet n Other tilmicosin premix n Other premix n Tilmovet Total drug exposure over time M ...

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  • Clinical field trials with tilmicosin phosphate in feed ...

    1996-2-1 · Two doses of tilmicosin phosphate (200 and 400 micrograms/g) and a 0 dose were administered in the feed for 21 days. Variables for determining efficacy were daily independent composite clinical impression score, individual pig weight, mortality, percentage of pneumonic involvement, and frequency of isolation of bacterial pathogens. Results

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  • Effects of two different doses of tilmicosin on pathogen ...

    groups treated with the 2 dosages of tilmicosin, 49.9% and 44.0% for 4.55 mg/lb and 9.1 mg/lb (10 mg/kg and 20 mg kg) treatments, respectively. 4 More recently, researchers evaluated the effects of tilmicosin administered at 6.75 mg/lb (14.85 mg/kg) BW on Mannheimia haemolytica and Histophilus somni con­

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  • www.arifsbd.com » Elanco Animal Health

    Efficacy : Pulmotil® AC is quickly absorbed and concentrates in respiratory tissues, and accumulates in phgocytes (macrophages, heterophils). Tilmicosin pulmonary and air sac concentrations persist at significant levels for at least 48 hours following application. This long payout provides extended protection and value for growers.

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  • Osmosis Nutrition – OMS Tilmicosin 200 mg/g premix

    2021-6-24 · Home Types of Animals Swine Osmosis Nutrition – OMS Tilmicosin 200 mg/g premix powder Indication: Treatment of respiratory disease and other organism’s susceptible to tilmicosin

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  • A comparison of florfenicol and tilmicosin for the ...

    However, interpretation of these observations must take into consideration the fact that these calves received meta-phylactic tilmicosin upon arrival at the feedlot, which is a standard, cost-effective, management procedure utilized by feedlots in western Canada. PMCID: PMC1539678 PMID: 10086218 [Indexed for MEDLINE] Publication Types: Clinical ...

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  • The efficacy of valnemulin (Econor®) in the control of ...

    2005-6-1 · Mycoplasma bovis infection was experimentally induced in groups of six young calves. A further group was uninfected and served as a control. Ten days after infection, medication with either enrofloxacin (Baytril, Bayer) or valnemulin (Econor, Novartis) was instituted via the milk replacer for a further 10 days, after which all calves were killed.

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  • Evaluation of the efficacy of tulathromycin as a ...

    The purpose of this study was to determine the efficacy and cost-effectiveness of tulathromycin (DRAX) versus tilmicosin (MIC) or oxytetracycline (TET) as a metaphylactic antimicrobial in feedlot calves. Calves that received DRAX had significantly (P<.05) lower initial undifferentiated fever (UF) treatment and relapse rates; lower overall chronicity, overall mortality, and cause-specific ...

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  • STUdY Of ThE EffICACY ANd SAfETY Of fLORfENICOL

    2019-2-6 · Study of the efficacy and Safety of florfenicol Premix (nuflor 40 mg/g Premix for medicated feeding Stuff for Swine) uSed in the Prevention and treatment of an outbreak of Porcine reSPiratory diSeaSe comPlex (Prdc) ANTONIO PALOMO YAgüE¹, JESúS bOLLO bERNAbé², RUT MENJÓN RUIz ², M. TERESA TEJEdOR3 ¹SETNA NUTRICIÓN S.A. – INzO IN vIvO .

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  • Veterinary Antibiotic-Tilmicosin - BALLYA

    2021-1-21 · According to the requirements, the mixing dosage is 200~400g/t, and the current market tilmicosin premix content is mostly 20%, that is, the concentration of 20% tilmicosin mixing material is 1~2kg/t, using multiple coating technology Tilmicosin has better efficacy in the same dosage.

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  • Comparison of tilmicosin and gamithromycin for

    Animals treated with tilmicosin or gamithromycin were not eligible for additional therapy until 5 days fol­ lowing treatment (i.e. 5-day minimum post-treatment interval (PTI)). Five days was the standard drug PTI used following treatment of cattle with tilmicosin at the participating feedlots. There is …

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  • FSA3012 Medicated Feed Additives for Cow-Calf and

    2021-5-10 · premix challenges medicated ... protectingthe safety and efficacy of medicallyimportant antimicrobials. Whilein the past, livestock producers ... • Tilmicosin(common name Pulmotil 90) – applies, veterinary feed directive applies, used only in cattle fed in for slaughter

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  • [PDF] Efficacy of Florfenicol Premix in Weaning Pigs ...

    27 ABSTRACT. The efficacy of a florfenicol premix was studied in weaning pigs experimentally inoculated with Actinobacillus pleuropneumoniae. Twenty five clinically healthy pigs were distributed into 3 groups; group A non-medicated, groups B and C orally medicated with 20 and 40 ppm of florfenicol respectively. The pigs were fed during 12 consecutive days and on day 5 all the groups were ...

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  • An evaluation of the relative efficacy of a new ...

    The relative efficacy of the LA 30 group, as compared with the LA 20 and FLOR groups, was assessed by comparing relapse, chronicity, wastage, and mortality rates. The overall mortality (RR = 0.50) rate in the LA 30 group was significantly (P < 0.05) lower than in the LA 20 group.

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  • Efficacy of switching from premix analog insulin twice ...

    2014-4-3 · Forty-four patients with type 2 diabetes receiving twice daily injections of premix analog insulin were randomly allocated to Group A in which patients were switched to long-acting insulin glargine at 80 % of the insulin dose in the previous treatment regimen (23 patients), or Group B (21 patients) given 50 % of the previous dose, concurrently with the oral dipeptidyl-4 inhibitor sitagliptin.

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  • Current Issues | Wjpps Controller

    2021-7-16 · comparative efficacy of colistin sulphate (enterocide® and biopharcoli)® against experimental infection with escherichia coli in broiler breeders Ashraf El-Komy* and Dr. Mohamed Aboubakr ABSTRACT (142) Article Download (12) [ DOI : 10.20959/wjpps20209-17097 ]

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  • Chloramphenicol and Derivatives, Macrolides,

    2018-2-8 · Therefore, the plasma drug concentration has been examined as a surrogate marker for efficacy from administration of macrolides and their derivatives. The parameter that is best suited to predict efficacy is the AUC of the plasma drug concentration to MIC (AUC/MIC) ratio (Drusano, 2005; Toutain et al., 2017).

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  • Pulmotil 90 contains 90.7 g tilmicosin phosphate per pound

    provide a Type B medicated feed containing up to 36,300 grams tilmicosin per ton or to provide a complete Type C medicated feed containing 181 to 363 g tilmicosin per ton. Do not use in any feeds containing bentonite. Bentonite in feeds may affect the efficacy of tilmicosin. Pulmotil 90 contains 90.7 g tilmicosin phosphate per pound

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  • DailyMed - PULMOTIL 90- tilmicosin phosphate granule

    Active Drug Ingredient: Tilmicosin (as tilmicosin phosphate) 90.7 g per lb (200 g per kg) Inert Ingredients: Ground corncobs. Close. Description: Pulmotil is a formulation of the antibiotic tilmicosin. Tilmicosin is produced semi-synthetically and is in the macrolide class of antibiotics. Each kilogram of Type A Medicated Article contains ...

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  • Pharmacokinetics and tissue depletion of tilmicosin in

    2020-7-29 · guidelines. The swine premix formulation of tilmicosin in feed was well tolerated by the turkeys and no adverse reactions were noted. The mean tissue concentrations of tilmicosin vs. time are shown in Fig. 1 and the pharmacokinetic parameters are shown in Table 3. Day 0 represents the last day that the turkeys received medicated feed.

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  • Enhanced Treatment Effects of Tilmicosin Against ...

    Tilmicosin is a semi-synthetic macrolide antibiotic, currently approved for veterinary use in cattle and swine respiratory disease, and is in development for use in poultry mycoplasma air sacculitis. In order to provide an understanding of clinical efficacy, the in vitro interaction of tilmicosin with three types of chicken phagocytes (MQ-NCSU macrophages, monocyte-macrophages, and heterophils ...

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  • [PDF] Intracellular accumulation, subcellular

    measured to determine efficacy of an on-arrival program, long-term growth and performance are also very important in determining the bottom-line effectiveness of a health management program. Materials and Methods Cattle Crossbred steers (n=l,370) with an average weight of 626 lb (285.4 kg) (range 466 to 795 lb; 212 to 361 kg) 18

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  • Comparison of tulathromycin, tildipirosin, and tilmicosin ...

    Methods: Recipient pigs, exposed to donor pigs that demonstrated clinical signs of PAR, either did not (NME group) or did (ME group) receive tilmicosin in feed for 3 weeks; a third Control group was neither exposed nor medicated. Pig weights and nasal swabs for bacterial culture were collected on study days 0, 21, and 42. Feed intake was also monitored.

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  • [PDF] The effect of tilmicosin in minimizing atrophic ...

    Bio-efficacy evaluation of premix formulation of sulfentrazone+clomazone against major weeds in soybean. Abstract An experiment was conducted during kharif 2014 and 2015 to evaluate the bio-efficacy of pre-mix formulation of sulfentrazone+clomazone as pre-emergence herbicide for season long weed control and higher productivity of soybean under ...

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  • Bio-efficacy evaluation of premix formulation of ...

    Diabetes is a lifelong course disease, so insulin treatment has to be effective and safe, and patients should be satisfied with it. We aimed to compare efficacy, safety, and quality of treatment satisfaction of human and premixed analogue insulin among 3264 patients (53.58% women) with type 2 diabetes mellitus (T2DM) in a real-life environment. 2493 patients (62.77%) had been assigned to group ...

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  • Efficacy, Safety, and Quality of Treatment Satisfaction

    2012-8-25 · Evaluation of the efficacy of tilmicosin phosphate premix (Pulmotil ™) to eliminate Actinobacillus pleuropneumoniae from the tonsils of carrier pigs. 2004. Proc. 18th IPVS Congress. Hamburg, Germany. P. 511. Kristensen CS, Andreasen M, Ersboll AK, Nielsen JP.Antibody response in …

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  • Pulmotil® (Tilmicosin) - Elanco Canada

    Efficacy dose determination study of tilmicosin phosphate in feed for control of pneumonia caused by Actinobacillus pleuropneumoniae in swine. American Journal of Veterinary Research. 57:220-223. 2 Langley, M., et al. 1994. Dose evaluation studies with Pulmotil (tilmicosin premix, Elanco) in the control of naturally occurring pneumonia in ...

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  • Pharmacokinetics of tilmicosin in healthy pigs and in

    A comparative in vivo pharmacokinetic (PK) study of tilmicosin (TIL) was conducted in 6 crossbred healthy pigs and 6 crossbred pigs infected with Haemophilus (H.) parasuis following oral administration of a single 40 mg/kg dose. The infected model was established by intranasal inoculation and confirmed by clinical signs, blood biochemistry, and microscopic examinations.

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  • Macrolides Final 2007 2-column

    2018-4-3 · sensitive than P. multocida to tilmicosin. Other gram-negative organisms tested,{R-91} including Enterobacter aerogenes, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Salmonella,{R-99} and Serratia species, are very resistant to tilmicosin.{R-91} Some strains of Actinomyces also are extremely resistant to tilmicosin.{R-99}

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  • Tilmicosin 200 (Canada) for Animal Use - Drugs.com

    2021-6-28 · Indication 4: TILMICOSIN 200 should be blended into an intermediate mix (premix or supplement) and then mixed into the complete diet (total mixed ration [TMR]) to supply 12.5 mg tilmicosin per kg of body weight (BW), equivalent to 200 ppm in feed for 7 days. This is achieved by the incorporation of 1 kg TILMICOSIN 200 per tonne of feed.

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  • Consensus on Initiation and Intensification of Premix ...

    Introduction: Premix insulin is the most commonly used insulin preparation in India. The first Indian premix guidelines were developed in 2009 and thereafter were updated in 2013. There is a need to revisit the Indian premix insulin guidelines, in view of emerging evidence and …

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  • Efficacy of Intramammary Pirlimycin as a Pre-calving ...

    2005-9-24 · Recently, more and more studies indicate that intramammary infection (IMI) in peripartum heifers are frequent and associated with financial losses. The objective of this study was to evaluate the effectiveness of an intramammary antibiotic treatment (pirlimycin) during the pre-calving period on the proportion of intramammary infection (IMI) in heifers at the onset of lactation as well as on ...

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  • Status of Bt Sweet Corn Performance and Insecticide ...

    2018-3-14 · efficacy was unrelated to corn earworm pressure, because moth activity monitored in blacklight traps has actually declined over the past decade at the farm sites. Sweet corn producers in the Mid-Atlantic growing Attribute® hybrids can apply insecticide sprays to compensate for th e reduced efficacy. Figure 2.

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  • The anti-nociceptive potential of tilmicosin against ...

    2015-10-30 · Tilmicosin is structurally related to tylosin, having the chemical formula (C 46 H 80 N 2 O 13) with a molecular weight of 869.15.Physically, it is freely soluble (1500 mg/L or greater) in organic solvents (hexane, acetone, acetonitrile, chloroform, dichloromethane, ethyl acetate, methanol, tetrahydrofuran); water solubility is temperature- and pH-dependent, but is 566 mg/mL at pH 7 and 25°C.

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  • 2020 AASV Annual Meeting Program

    The speakers all have experience in different areas and topics relating to the control and management of FADs. The seminar will focus on African swine fever but will cover and apply to other relevant transboundary and foreign animal diseases as well. 8:00 Pig …

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  • Impact of storage conditions and premix type on

    2020-4-24 · A VP and VTM premix were manufactured as outlined in Table 1. Ingredients were mixed for 5 min in 47.6-kg batches using a 0.085-m 3 paddle mixer (Davis model 2014197-SS-S1, Bonner Springs, KS). Then, each premix was equally discharged into three separate 15.9-kg aliquots.

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  • Pulmotil (tilmicosin) Veterinary Feed Directive for use in ...

    2016-11-3 · VFDs for tilmicosin phosphate shall not be refilled. Complete Type C medicated feeds containing tilmicosin should not be pelleted. Do not use in any feeds containing bentonite, cottonseed meal, or cottonseed hulls. Bentonite, cottonseed meal, or cottonseed hulls in feeds may affect the efficacy of tilmicosin.

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  • Effect of Bromhexine on the Pharmacokinetic of

    Tilmicosin standard concentrations of 0.03, 0.06, 0.15, 0.3, 0.6, 1.5 and 3 μg/ml and their corresponding peak responses are illustrated in Table (1) and Fig. (1), and Typical Chromatogram of tilmicosin are illustrated in Fig. (2). the calibration curve was calculated by linear regression equation method as y= 1538.5x + 21.755 where ‘y ...

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  • 21 CFR § 558.618 - Tilmicosin. | CFR | US Law | LII ...

    2021-4-26 · Tilmicosin phosphate in grams/ton Combination in grams/ton Indications for use Limitations Sponsor (i) 181 to 363: Swine: For the control of swine respiratory disease associated with Actinobacillus pleuropneumoniae and Pasteurella multocida: Feed continuously as the sole ration for 21-day period, beginning approximately 7 days before an anticipated disease outbreak.

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  • Prudent Use of Antibiotics | Huvepharma

    2020-8-11 · Two types of antibiotics with an ideal PK profile regarding efficacy The formulation of the veterinary medicine can also influence the clinical outcome of an antimicrobial treatment. Stability, solubility and bioavailability of the active can be optimized by the choice of excipients and the manufacturing method.

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  • Pharmacokinetics and tissue depletion of tilmicosin in ...

    2008-12-1 · In addition, intracellular tilmicosin increases cellular lysosomal production in all three chicken phagocyte types ( Scorneaux & Shryock, 1998 ). Therefore, it is suggested that these intracellular concentrations contribute to tilmicosin’s efficacy in respiratory tract infections in a way not predicted by serum or lung homogenate concentrations.

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  • Efficacy of separate and premix formulation of

    2013-3-23 · Efficacy of separate and premix formulation of herbicides on weeds, 978-3-659-37613-9, 9783659376139, 3659376132, Agriculture, horticulture, forestry, fishery, nutrition , Wheat (Triticum aestivum L.) is second most important food grain crop of India and is associated with the food security of the country.India needs more food around 105 million tonnes for feeding the increasing population by ...

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  • Efficacy of Separate and Premix Formulation of

    2013-3-29 · Efficacy of Separate and Premix Formulation of Herbicides on Weeds 72. by Kumar Rakesh, Paswan Ajit Kumar (Editor) ... the commercially available herbicides are mixture of grassy and non-grassy herbicides and have efficiency against these types of weeds only. Therefore, targeted weed control mixtures are required to prevent resistance in one or ...

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  • Importance Ratings and Summary of Antibacterial Uses in ...

    Each antibacterial is evaluated for quality, safety to humans, the environment and the target host animal, efficacy and trade implications. The safety evaluation includes the management of risks associated with the development of antibacterial resistant organisms in animals that may be transferred to humans.

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  • Premix of vitamins, minerals and additives for feed ...

    2015-3-4 · Efficacy and Safety of Insulin Degludec in Japanese Patients and International Phase 3 Trials. An extensive phase 3 clinical development program of insulin degludec has been completed, with numerous studies carried out in many countries, including Japan, of patients with type 1 diabetes mellitus or type 2 diabetes mellitus.

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  • Efficacy of Tilmicosin (Pulmotil ®) for control of swine ...

    Olson, Linda; Backstrom, Lennart. (1999). Efficacy of Tilmicosin (Pulmotil ®) for control of swine progressive atrophic rhinitis (AR) involving infection with Pasteurella multocida.

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  • Liquid chromatographic determination of tilmicosin in ...

    1997-11-1 · Efficacy of tilmicosin phosphate (Pulmotil premix) in feed for the treatment of a clinical outbreak of Actinobacillus pleuropneumoniae infection in growing-finishing pigs. Hoflack G, Maes D, Mateusen B, Verdonck M, de Kruif A. J Vet Med B Infect Dis Vet Public Health, 48(9):655-664, 01 …

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  • Comparative Efficacy of DRAXXIN vs Zuprevo or Micotil

    # A similar protocol but using Micotil® (tilmicosin) for arrival control of BRD with a 3-day PMI. # A 7-day post-treatment interval (PTI) was observed after initial EXCEDE treatment. • Cattle that received arrival DRAXXIN experienced at least 23% better metaphylaxis success rates (no BRD) at days 28 and 56 (P < 0.01), at least 76% fewer combined

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  • Efficacy and Safety of Basal Insulin Glargine

    2015-6-10 · This is a multicentre, open-label, randomized and parallel trial that will compare the efficacy and safety of basal insulin glargine combination with Exenatide bid vs. switching premix human insulin to aspart30 in type 2 diabetic patients with inadequate glycaemic control on …

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  • the Efficacy of Acarbose and Metformin on Blood

    2015-5-8 · Premix Insulin therapy for more than 3 months, the daily dosage of insulin >20IU and <1IU/kg; 30 ≤Age ≤ 70 years old, male or female; 7.0 ≤ HbA1c ≤10.0%; 18.5≤ BMI ≤ 35 kg/m2; Written Informed consent; Exclusion Criteria: Subject with type 1 diabetes or gestational diabetes mellitus and other specific types DM

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  • LSD1 silencing contributes to enhanced efficacy of

    2021-3-17 · All of the above cell types were cultured at 37 °C in a cell incubator with 5% CO 2. RNA interference (RNAi) and gene transfection The LSD1 small …

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  • Antimicrobial susceptibility profiles of porcine ...

    2020-9-3 · Mycoplasma (M.) hyopneumoniae, M. hyorhinis and M. hyosynoviae are significant pathogens for the porcine industry worldwide. The aim of the present study was to determine the antimicrobial susceptibility of six key antimicrobials (tylosin, tilmicosin, tylvalosin, lincomycin, tiamulin and valnemulin) routinely used for treating infections caused by these pathogens.

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  • Efficacy of dicamba and glyphosate as influenced by ...

    control efficacy of a dicamba-and-glyphosate mixture. This study was conducted to evaluate the effect of carrier water pH and hardness on efficacy of a premix of low-volatility dicamba and glyphosate for weed control. Materials and Methods Field Studies Field experiments were conducted in the summer of 2013 and 2014 in the absence of a crop.

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  • Key to All Types of Trace Mineral Deficiency - Zagro

    2017-3-15 · The efficacy of trace minerals is an important issue in modern poultry nutrition. Micro minerals are essential for normal growth and many metabolic processes in living organisms, as they are catalysts or constituents of the enzymatic systems in many cells. They play a vital role in various metabolic, enzymatic and

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  • Pharmacokinetics of veterinary drugs in laying hens

    Many drugs deposit preferentially in the yolk or albumen, depending on the drug’s physicochemical properties. Some characteristics that effect the distribution of residues are the drug’s tendency to bind to plasma proteins, hydrophobicity or hydrophilicity, and the ability to move through different tissue types (Martinez, 1998).However, a drug’s kinetic properties cannot always be ...

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  • Antiviral Activity of Tilmicosin for Type 1 and Type 2 ...

    2019-3-28 · One potential antiviral drug is tilmicosin, a chemically modified macrolide antibiotic derivative of tylosin, which is synthesized in Streptomyces fradiae. Tilmicosin has been developed for veterinary use as an injectable for use in cattle and sheep and as a premix feed formulation for swine [15].

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  • Capsaicin enhances anti-proliferation efficacy of ...

    The recurrence of bladder cancer after surgery with or without chemotherapy remains a major challenge in bladder cancer treatment. Previous studies have shown that transient receptor potential vanilloid 1 (TRPV1) acts as a tumor suppressor through inducing apoptosis in bladder cancer cells. However, whether activation of TRPV1 has any synergistic effects with pirarubicin (THP), one of main ...

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  • The Efficacy of Selected Iron Fortificants in Improving ...

    2015-6-22 · the efficacy of two types of iron fortificants that could be used to fortify rice, in improving the iron status of schoolchildren. Methods: One hundred eighty anemic schoolchildren, aged 7-8 years, in a Pasig City public elementary school, participated in a doubly-masked-randomized controlled feeding trial for …

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  • A Pilot Study in Sweden on Efficacy of Benzylpenicillin ...

    Bovine respiratory disease (BRD) is a major indication for antibiotic treatment of cattle worldwide and some of the antibiotics used belong to classes of highest priority among those listed by WHO as critically important for human medicine. To preserve the efficacy of “newer” antibiotics, it has been suggested that “older” drugs should be revisited and used when possible.

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  • Efficacy and Safety of Basal Analog Regimens in Type

    2019-4-6 · This study compared basal analog (BA: glargine U100/mL and detemir) and premix (PM: human, lispro and aspart biphasic) insulin regimens in terms of their efficacy and safety in type 2 diabetes mellitus patients. Searches of MEDLINE, Embase, and CENTRAL identified primary randomized controlled trials (RCTs) ≥ 12 weeks in duration that compared BA or PM insulin regimens in adults …

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  • Safety and efficacy of copper chelates of lysine and ...

    2019-6-18 · The approach followed by the FEEDAP Panel to assess the safety and the efficacy of copper chelates of lysine and glutamic acid is in line with the principles laid down in Regulation (EC) No 429/20086 6 Commission Regulation (EC) No 429/2008 of 25 April 2008 on detailed rules for the implementation of Regulation (EC) No 1831/2003 of the European ...

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  • Monteban™ 100 Anticoccidial Premix | Grow Solutions

    2021-7-16 · Monteban™ 100 Anticoccidial Premix. Monteban™ is indicated as an aid in the prevention of coccidiosis caused by Eimeria acervulina, E. brunetti, E. maxima, E. mivati, E. necatrix and E. tenella. The active component in Monteban™ is narasin, an ionophore with a proven track record of controlling coccidiosis and in maintaining a high level ...

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  • Medication sequencing guideline for management of

    Some feed manufacturing facilities use medications (drugs) in the production of feed products. This document describes the policy the Canadian Food Inspection Agency (CFIA) will use to determine if these facilities have developed and are using the necessary procedures and controls intended to mitigate the risks associated with the use of medications in their facility, such as the carryover of ...

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  • Colistin Sulfate (10%, 20%) Premix - China -

    Montrez un peu d'amour à vos animaux de compagnie et à votre bétail avec des offres prémélange tilmicosine prix inégalées sur Alibaba.com. Le prémélange tilmicosine prix les maintiendra dans un état étincelant de santé incroyable.

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